Stat2 Binding to the Interferon-α Receptor 2 Subunit Is Not Required for Interferon-α Signaling
نویسندگان
چکیده
منابع مشابه
Dengue virus inhibits interferon-α signaling by reducing STAT2 expression
DDRC, Queen Mary’s School of Medicine and Dentistry, Newark Street, London E1 2AD, UK; Department of Pathology and Microbiology, University of Bristol, University Walk, Bristol BS8 1TD, UK; Department of Gastroenterology and Hepatology, University Hospital of Essen, Hufelandstr. 55, 45122 Essen, Germany; Centre for Hepatology, Royal Free & University College Medical School, Rowland Hill Street,...
متن کاملInterferon-β is required for interferon-α production in mouse fibroblasts
The type I interferons — interferon-a (IFN-a) and interferon-b (IFN-b) — are critical for protection against viruses during the acute stage of viral infection [1,2]. Furthermore, type I interferons have been implicated as important mediators in the regulation of lymphocyte development [3], immune responses [4,5] and the maintenance of immunological memory of cytotoxic T cells [6,7]. The differe...
متن کاملSTAT1 is essential for the inhibition of hepatitis C virus replication by interferon-λ but not by interferon-α
Interferon-α (IFN-α) and IFN-λ are structurally distinct cytokines that bind to different receptors, but induce expression of similar sets of genes through Janus kinase (JAK)-signal transducers and activators of transcription (STAT) pathways. The difference between IFN-α and IFN-λ signaling remains poorly understood. Here, using the CRISPR/Cas9 system, we examine the role of STAT1 and STAT2 in ...
متن کاملInterpreting interest in interferon-α
Systemic lupus erythematosus (SLE) is a chronic auto-immune disease that affects approximately 0.1% of the population, with most afflicted individuals being young women. SLE is characterized by inflammatory destruction of skin, blood elements, joints, kidneys, serosa, central nervous system, and other tissues [1]. Despite intensive efforts by many investigators, the cellular and molecular mecha...
متن کاملMx Is Not Responsible for the Antiviral Activity of Interferon-α against Japanese Encephalitis Virus
Mx proteins are interferon (IFN)-induced dynamin-like GTPases that are present in all vertebrates and inhibit the replication of myriad viruses. However, the role Mx proteins play in IFN-mediated suppression of Japanese encephalitis virus (JEV) infection is unknown. In this study, we set out to investigate the effects of Mx1 and Mx2 expression on the interferon-α (IFNα) restriction of JEV repli...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2002
ISSN: 0021-9258
DOI: 10.1074/jbc.m111161200